Mosaic tile model for tRNA-enzyme recognition

Steinberg, S.V.; Kisselev, L.L.

Mosaic tile model for tRNA-enzyme recognition

1993

Steinberg, S.V. | Kisselev, L.L.

An improved algorithm was elaborated to analyse tRNA interaction with aminoacyl-tRNA synthetase based on analysis of tRNA sequences. The fundamental element defining the interaction between the tRNA and the synthetase is not a single nucleotide but a nucleotide combination named a tile which comprises of a given nucleotide and its neighbours as they are defined by the tertiary structure of the molecule. Informational content of each tile is calculated as its probability to occur exclusively in a set of cognate tRNAs. Based on this algorithm the identity sites of E. coli tRNA(Ala) and tRNA(Gln) were determined. The results are in a good agreement with the biochemical data and provide new information about identity sites of these tRNAs.

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AGROVOC Keywords

ala algorithms algorithms amino acids binding sites escherichia coli genetics ligases metabolism models nucleotides rna rna rna rna transfer rna

Bibliographic information

Published in

Nucleic acids research

ISSN 0305-1048

Publisher

Oxford, UK : Blackwell Publishing Ltd

Other Subjects

Genetic; Amino acyl-trna synthetases; Transfer; Transfer; Gln; Aminoacyl-trna synthetase; Bacterial; Nucleotide combinations; Transfer; Nucleotide sequences; Molecular conformation; Informational tiles

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-29

Format: MODS

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Mosaic tile model for tRNA-enzyme recognition

1993

AGROVOC Keywords

Bibliographic information