9-(3,4-Dimethyl-5-pentyl-furan-2-yl) nonanoic Acid and 9-(3,4-DimethyI-5-propyl-furan-2-yl) nonanoic Acid: New Naturally Occurring Peroxidase Inhibitors
2014
Fuchs, Claus T. | Spiteller, G. (Gerhard)
9-(3,4-Dimethyl-5-pentyl-furan-2-yl) nonanoic acid [diMeF(9,5)] and 9-(3,4-dimethyl-5-propyl-furan-2-yl) nonanoic acid [diMeF(9,3)] and its corresponding methyl esters have been assayed for inhibitory activity on horseradish peroxidase (E C 1.11.1.17) by measuring the peroxidase-catalyse decomposition of indole-3-acetic acid. Both compounds and their meth-ylates are com petitive inhibitors to horseradish peroxidase with inhibitor constants (K₁) of 50 ± 0.9 × 10⁻⁵ ᴍ respectively 5.2 ± 0.8 × 10⁻⁵ ᴍ. Development of inhibitory effect requires not only the presence of the furan heterocycle but also of a polar side chain.
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