Vitamin B6 deficiency in maintenance dialysis patients: Metabolic effects of repletion
1980
Kleiner, Morton J. | Tate, Surresh S. | Sullivan, John F. | Chami, Jacqueline
Vitamin B6 deficiency may contribute significantly to the abnormal protein and lipid metabolism of dialysis patients. EGOT activity was lower in dialysis patients than in controls; EGOT indices did not differ significantly between groups. After 14 days of oral pyridoxine supplementation, EGOT activity in dialysis patients was similar to controls. Serum high-density lipoprotein levels increased significantly; serum cholesterol and triglyceride levels did not change. Immune responsiveness was in the normal range before and after supplementation. Metabolic clearance rate for essential amino acids was significantly lower in dialysis patients and did not improve with supplementation. Fasting plasma levels of valine, leucine, tryptophan, serine, glutamine, alanine, and tyrosine were significantly lower in dialysis patients. After supplementation, all except tryptophan and tyrosine increased to the level of controls; those two did not change.
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