Palm gamma-tocotrienol supplementation suppress tumour growth and metastasis in a syngeneic mouse model of breast cancer
2022
Shonia Subramaniam | Ammu Kutty Radhakrishnan | Jeya Seela Anandha Rao | Premdass Ramdas | Ng, Mei Han | Methil Kannan Kutty | Kanga Rani Selvaduray
Gamma-tocotrienol (γT3) is an isoform of vitamin E found abundantly in palm oil, which is reported to possess antioxidant and anticancer activities. However, the immune-modulating properties of γT3 have yet to be elucidated. Breast cancer (BC) was induced in female BALB/c mice by injecting 4T1 murine mammary cancer cells into their mammary fat pads. When the tumour was palpable, the animals were randomly assigned into two groups: (i) control [fed twice daily with 50 μL vehicle (soy oil)] or (ii) experimental (fed twice daily with 50 μL of 0.5 mg of γT3). Results show that mice fed with γT3 had reduced tumour growth and metastasis. However, there are no marked changes in the percentages of peripheral blood leukocytes and cytokines production in these animals. Immunohistochemistry using antibodies to murine CD4, IL12Rβ2, IL24 and FoxP3 on tumour sections from γT3 treated mice suggested that γT3 induced suppression of tumour growth and metastasis as well as reduced immunosuppression in the tumour microenvironment. It can be concluded that, γT3 has the potential to suppress tumour growth and metastasis in this model. Further investigation on the host immune response is possible by prolonging treatment duration against BC.
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