Resveratrol supplementation reduces oxidative stress and modulates the immune response in free-living animals during a viral infection
2018
Sebastiano, Manrico | Eens, Marcel | Messina, Simone | Abdelgawad, Hamada | Pineau, Kévin | Beemster, Gerrit | Chastel, Olivier | Costantini, David | Hawley, Dana | Behavioural Ecology & Ecophysiology Group, ; Universiteit Antwerpen = University of Antwerp | Universiteit Antwerpen = University of Antwerp | Groupe d’Etude et de Protection des Oiseaux en Guyane (GEPOG) ; Groupe d’Etude et de Protection des Oiseaux en Guyane (GEPOG) | Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) ; Institut National de la Recherche Agronomique (INRA)-La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)
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Show more [+] Less [-]English. 1. Diet quality may have an important effect on the regulation of oxidative statusand the immune system during an infectious disease. However, the relationshipamong intake of specific dietary molecules, an individual’s oxidative status and theoccurrence and progress of a viral disease remains almost unexplored in free‐livingorganisms.2. Here, we study a wild, long‐lived animal, the Magnificent frigatebird Fregata magnificensto investigate: (a) the differences in a number of physiological traits (biomarkersof blood oxidative status, corticosterone (CORT), immunity andinflammation) between sick and healthy nestlings; and (b) whether experimentallyincreased intake of resveratrol (a polyphenol with antioxidant and antiviral properties)affects these physiological markers during the progress of a severe viraldisease.3. Birds with visible clinical signs showed higher oxidative damage, haemolysis andhaemagglutination scores and lower antioxidant defences in comparison withbirds without clinical signs. At the end of the experiment, supplemented birdsshowed the following: (a) increased plasma haptoglobin levels and circulating antioxidantdefences; (b) reduced generation of lipid oxidative damage; and (c) negligibleto no influence on immune markers, baseline CORT levels and activity ofantioxidant enzymes.4. Our work illustrates how the availability of specific organic molecules in the dietmay constrain the individuals’ capacity to cope with viral infections in free‐livinganimals
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