Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling

Mezo‐gonzález, Carla, Elena; García‐santillán, Juan, Antonio; Kaeffer, Bertrand; Gourdel, Mathilde; Croyal, Mikaël; Bolaños‐jiménez, Francisco; Physiopathologie des Adaptations Nutritionnelles  ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement -Nantes Université - UFR de Médecine et des Techniques Médicales  ; Nantes Université - pôle Santé ; Nantes Université -Nantes Université -Nantes Université - pôle Santé ; Nantes Université -Nantes Université; ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291  ; Institut National de la Santé et de la Recherche Médicale -Centre National de la Recherche Scientifique -Nantes Université - UFR de Médecine et des Techniques Médicales  ; Nantes Université - pôle Santé ; Nantes Université -Nantes Université -Nantes Université - pôle Santé ; Nantes Université -Nantes Université; Consejo Nacional de Ciencia yTecnologia, Mexico, Grant/AwardNumber: ANR-16-CE21-0007-01;French National Research Agency,Grant/Award Number: 2015-16-273510

Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling

2024

Mezo‐gonzález, Carla, Elena | García‐santillán, Juan, Antonio | Kaeffer, Bertrand | Gourdel, Mathilde | Croyal, Mikaël | Bolaños‐jiménez, Francisco | Physiopathologie des Adaptations Nutritionnelles (PhAN) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE) ; Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) | ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX-lab) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE) ; Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) | Consejo Nacional de Ciencia yTecnologia, Mexico, Grant/AwardNumber: ANR-16-CE21-0007-01;French National Research Agency,Grant/Award Number: 2015-16-273510

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English. Aim: Offspring of obese mothers are at high risk of developing metabolic syndrome and cognitive disabilities. Impaired metabolism has also been reported in the offspring of obese fathers. However, whether brain function can also be affected by paternal obesity has barely been examined. This study aimed to characterize the learning deficits resulting from paternal obesity versus those induced by maternal obesity and to identify the underlying mechanisms.

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AGROVOC Keywords

learning

Bibliographic information

Publisher

CCSD, Wiley

Other Subjects

Paternal obesity; [sdv]life sciences [q-bio]; Kynurenine pathway; Glutamate signaling; Developmental programming

Language

English

License

http://creativecommons.org/licenses/by-nc-nd/, info:eu-repo/semantics/OpenAccess

ISBN

0011432743000

ISSN

04402176, 38230587

Type

Journal Article; Journal Part; Journal Article; Journal Part

Source

ISSN: 1748-1708, EISSN: 1748-1716, Acta Physiologica, https://hal.science/hal-04402176, Acta Physiologica, 2024, 240 (3), ⟨10.1111/apha.14090⟩

In AGRIS since: 2024-03-20

Modification date: 2025-10-24

Format: Dublin Core

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DOI https://hal.science/hal-04402176 https://hal.science/hal-04402176v1/document https://hal.science/hal-04402176v1/file/Acta%20Physiologica%20-%202024%20-%20Mezo%E2%80%90Gonz%C3%A1lez%20-%20Adult%20rats%20sired%20by%20obese%20fathers%20present%20learning%20deficits%20associated%20with.pdf

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Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling

2024

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