Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper
2013
Stafford, Sian, L | Bokil, Nilesh, J | Achard, Maud, E S | Kapetanovic, Ronan | Schembri, Mark, A | Mcewan, Alastair, G | Sweet, Matthew, J | Australian Infectious Diseases Research Centre ; University of Queensland [Brisbane] | School of Chemistry and Molecular Biosciences ; University of Queensland [Brisbane] | Institute for Molecular Bioscience ; University of Queensland [Brisbane] | This work was supported by project grants from the National Health and Medical Research Council of Australia [grant numbers ID631531 (to M.J.S.), ID519722 (to A.G.M. and M.A.S.)]. M.A.S. and M.J.S. are the recipients of Australian Research Council Future Fellowships [grant numbers FT100100662 and FT100100657] and M.J.S. holds an honorary NHMRC Senior Research Fellowship [grant number APP1003470]. R.K. is supported by an ARC DECRAFellowship [grant number DE130100470]. S.L.S. is the recipient of a University of Queensland Postgraduate Scholarship, and N.J.B. is the recipient of an Endeavour international postgraduate research scholarship and a University of Queensland research scholarship.
International audience
Show more [+] Less [-]English. The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial growth and survival. This presents opportunities for the host to either harness their antimicrobial properties or limit their availability as defence strategies. Recent studies have shed some light on mechanisms by which copper and zinc regulation contribute to host defence, but there remain many unanswered questions at the cellular and molecular levels. Here we review the roles of these two metal ions in providing protection against infectious diseases in vivo, and in regulating innate immune responses. In particular, we focus on studies implicating zinc and copper in macrophage antimicrobial pathways, as well as the specific host genes encoding zinc transporters (SLC30A, SLC39A family members) and CTRs (copper transporters, ATP7 family members) that may contribute to pathogen control by these cells.
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