Pea Albumin 1 Subunit b (PA1b), a Promising Bioinsecticide of Plant Origin.
2011
Gressent, Frédéric | da Silva, Pedro | Eyraud, Vanessa | Karaki, Lamis | Royer, Corinne | Biologie Fonctionnelle, Insectes et Interactions (BF2I) ; Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA) | We thank V. James for the English corrections. The work on PA1b in Lyon was supported by Region Centre and Rhone-Alpes, by the IFR41, the ANR and INSA-Lyon. We would like to pay special homage to the late Bernard Delobel, who first discovered the insecticidal property of PA1b.
International audience
Show more [+] Less [-]English. PA1b (Pea Albumin 1, subunit b) is a peptide extract from pea seeds showing significant insecticidal activity against certain insects, such as cereal weevils (genus Sitophilus), the mosquitoes Culex pipiens and Aedes aegyptii, and certain species of aphids. PA1b has great potential for use on an industrial scale and for use in organic farming: it is extracted from a common plant; it is a peptide (and therefore suitable for transgenic applications); it can withstand many steps of extraction and purification without losing its activity; and it is present in a seed regularly consumed by humans and mammals without any known toxicity or allergenicity. The potential of this peptide to limit pest damage has stimulated research concerning its host range, its mechanism of action, its three-dimensional structure, the natural diversity of PA1b and its structure-function relationships.
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