Assessment the efficacy of some herbes in the prevention of steroid induced hepatopathy in dog
2024
Nehal Elhosiny | Abdel Raouf M. Mahmoud | Hatem M. Selim | Heba Gouda
Medicinal plants play a crucial role in the treatment and prevention of steroid- induced hepatopathy. The purpose of the study was to evaluate the ability of some herbes to reduce the steroid- induced hepatopathy. Twenty mongrel dogs were included in the experimental study. Dogs were divided into four groups each group consisting of five animals; Group I received dexamethasone, Group II received dexamethasone and concentrated milk thistle (silymarin), Group III received dexamethasone and L-carnitine, Group IV received dexamethasone and liquorice powder. Clinical, blood samples, ultrasound were done on days 0, 7, 14 and 21. Haemato- biochemical analysis indicated a significant increase in hemoglobin (Hb) concentration and hematocrit value, a significant decrease in white blood cells count, a significant decrease in alkaline phosphatase (ALP) activity and a significant increase in total protein and albumin levels in silymarin treated Group II, L-carnitine treated Group III and liquorice treated Group IV compared to Group I. Ultrasonography revealed an increase in echogenicity of liver parenchyma in hepatopathic induced dogs and returned to nearly normal in Group II and Group III. In conclusion, the medicinal plants have a potential effect in treatment and prevention of steroid induced hepatopathy.
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