Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies
2021
Valarcher, Jean, François | Hägglund, Sara | Näslund, Katarina | Jouneau, Luc | Malmström, Ester | Boulesteix, Olivier | Pinard, Anne | Leguéré, Dany | Deslis, Alain | Gauthier, David | Dubuquoy, Catherine | Pietralunga, Vincent | Remot, Aude | Falk, Alexander | Shevchenko, Ganna | Bergström Lind, Sara | von Brömssen, Claudia | Vargmar, Karin | Zhang, Baoshan | Kwong, Peter, D | Rodriguez, María Jose | Garcia Duran, Marga | Schwartz-Cornil, Isabelle | Taylor, Geraldine | Riffault, Sabine | Department of Clinical Sciences ; Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet (SLU) | Virologie et Immunologie Moléculaires (VIM (UR 0892)) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Plateforme d'Infectiologie Expérimentale (PFIE) ; Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Infectiologie et Santé Publique (ISP) ; Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Department of Chemistry [Uppsala, Sueden] ; Biomedical Center = Biomedicinskt centrum [Uppsala, Sueden] (BMC) ; Uppsala University-Uppsala University | Department of Energy and Technology ; Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet (SLU) | Department of Biomedicine and Veterinary Public Health ; Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet (SLU) | Vaccine Research Center (VRC) ; National Institutes of Health [Bethesda, MD, USA] (NIH) | INGENASA | The Pirbright Institute ; Biotechnology and Biological Sciences Research Council (BBSRC) | Swedish Foundation of Strategic Research (SB16-0039) ; Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) (USA) | European Project: 633184,H2020,H2020-SFS-2014-2,SAPHIR(2015)
International audience
Show more [+] Less [-]English. The induction of long-lasting clinical and virological protection is needed for a successful vaccination program against the bovine respiratory syncytial virus (BRSV). In this study, calves with BRSV-specific maternally derived antibodies were vaccinated once, either with (i) a BRSV pre-fusion protein (PreF) and MontanideTM ISA61 VG (ISA61, n = 6), (ii) BRSV lacking the SH gene (ΔSHrBRSV, n = 6), (iii) a commercial vaccine (CV, n = 6), or were injected with ISA61 alone (n = 6). All calves were challenged with BRSV 92 days later and were euthanized 13 days post-infection. Based on clinical, pathological, and proteomic data, all vaccines appeared safe. Compared to the controls, PreF induced the most significant clinical and virological protection post-challenge, followed by ΔSHrBRSV and CV, whereas the protection of PreF-vaccinated calves was correlated with BRSV-specific serum immunoglobulin (Ig)G antibody responses 84 days post-vaccination, and the IgG antibody titers of ΔSHrBRSV- and CV-vaccinated calves did not differ from the controls on this day. Nevertheless, strong anamnestic BRSV- and PreF-specific IgG responses occurred in calves vaccinated with either of the vaccines, following a BRSV challenge. In conclusion, PreF and ΔSHrBRSV are two efficient one-shot candidate vaccines. By inducing a protection for at least three months, they could potentially improve the control of BRSV in calves.
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