In vitro susceptibility testing of Candida and Aspergillus spp. to voriconazole and other antifungal agents using Etest ® : results of a French multicentre study
2005
Mallie, Michele | Bastide, Jean-Marie | Blancard, A. | Bonnin, Alain | Bretagne, Stéphane | Cambon, M. | Chandenier, Jacques | Chauveau, Veronique | Couprie, Bernard | Datry, A. | Feuilhade, Martine | Grillot, Renée | Guiguen, Claude | Lavarde, Véronique | Letscher, Valérie | Linas, Marie Denise | Michel, A. | Morin, Odile | Paugam, André | Piens, Marie-Antoinette | Raberin, Hélène | Tissot, E. | Toubas, Dominique | Wade, A. | Université Montpellier 1 (UM1) | Hôpital de la Timone [CHU - APHM] (TIMONE) | Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) | Unité mixte de recherche biologie moléculaire et immunologie parasitaires et fongiques ; Agence Française de Sécurité Sanitaire des Aliments (AFSSA)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) | Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Hôpital Hôtel-Dieu de Clermont-Ferrand ; CHU Clermont-Ferrand | Hôpital Bretonneau ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bretonneau | Pfizer | Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux) | CHU Pitié-Salpêtrière [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) | Hopital Saint-Louis [AP-HP] (AP-HP) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA) | Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] | Université de Strasbourg (UNISTRA) | Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) | Assistance Publique - Hôpitaux de Marseille (APHM) | Université de Nantes (UN) | Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon | Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E) | Hôpital Maison Blanche ; Hôpital universitaire Robert Debré [Reims] (CHU Reims)
International audience
Show more [+] Less [-]English. Minimum inhibitory concentrations (MICs) of the antifungal agent voriconazole were determined using the Etest(R) and compared with those of amphotericin B. itraconazole and fluconazole using 1986 clinical isolates of Candida spp. Voriconazole MICs were also compared with those of amphotericin B and itraconazole using 391 clinical isolates of Aspergillus spp. Voriconazole was found to have more potent activity and lower MIC values than amphotericin B, itraconazole and fluconazole against C. albicans, C. tropicalis, C. parapsilosis and C. kefyr. Against C. glabrata and C. krusei, voriconazole was more active than either of the other two azole antifungals but had similar activity to amphotericin B. For species of Aspergillus, MIC values of voriconazole were lower than those of amphotericin B and itraconazole against A. fumigatus and A. flavus, and were similar to those of amphotericin B against A. niger. Against A. terreus, MIC values for voriconazole and itraconazole were similar. A. terreus is known to be resistant to amphotericin B, and this was reflected in higher MIC values compared with those of voriconazole and itraconazole. Voriconazole therefore compares very favourably with other antifungal agents against a large number of clinical isolates of Candida and Aspergillus spp.
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