An Easy Stereoselective Copper(I)-Catalyzed Synthesis of (E)-3-Trifluoromethylbut-2-en-3-ynoate via Palladium-Free Stille Coupling Reaction
2012
Zine, Khalid | Petrignet, J. | Thibonnet, Jérôme | Abarbri, Mohamed | Université de Tours (UT) | Infectiologie et Santé Publique (UMR ISP) ; Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)
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Show more [+] Less [-]English. A general and efficient Cu(I)-catalyzed cross-coupling reaction of alkynyl bromides and beta-tributylstannyl-alpha, beta-unsaturated ester bearing a trifluoromethyl group in beta-position was developed under very mild conditions. This method provides easy access to a variety of 2,3-enynoate bearing a trifluoromethyl group from good to excellent yields with excellent stereoselectivity. This procedure does not require the use of any expensive supplementary additives and is palladium-free.
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