Effects of dietary beef, pork, chicken and salmon on intestinal carcinogenesis in A/J Min/ plus mice
2017
Steppeler, Christina | Sodring, Marianne | Egelandsdal, Bjorg | Kirkhus, Bente | Oostindjer, Marije | Alvseike, Ole | Gangsei, Lars Erik | Hovland, Ellen-Margrethe | Pierre, Fabrice H.F. | Paulsen, Jan Erik | Department of Food Safety and Infection Biology ; Norwegian School of Veterinary Science | Department of Chemistry, Biotechnology and Food Science ; Norwegian University of Life Sciences (NMBU) | Norwegian Institute of Food,Fisheries and Aquaculture Research (NOFIMA) | Norwegian Meat Research Centre ; Partenaires INRAE | Prévention et promotion de la cancérogénèse par les aliments (ToxAlim-PPCA) ; ToxAlim (ToxAlim) ; Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | CS was financed by the Norwegian Agriculture Agency (100%, but with the restriction that 1/5 is jointly reimbursed by the Norwegian Meat Industry and the National Levy on Meat and Egg). MS was financed by the Norwegian Agriculture Agency (100%, but with the restriction that 1/4 is jointly reimbursed by the Norwegian Meat Industry). BG was financed by the Ministry of Education and Research (100%). BK was financed by the Norwegian Agriculture Agency (100%, but with the restriction that 1/5 is jointly reimbursed by the Norwegian Meat Industry and the National Levy on Meat and Egg). MO was financed by the Norwegian Agriculture Agency (100%, but with the restriction that 1/5 is jointly reimbursed by the Norwegian Meat Industry and the National Levy on Meat and Egg). OA, LEG and EMH were financed by Animalia-Norwegian Meat and Poultry Research Center (100%), mainly financed by the National Levy on Meat and Egg. FP was financed by the French National Institute for Agricultural Research (INRA) (100%). JEP were financed by the Ministry of Education and Research (100%). The funders did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.
The International Agency for Research on Cancer has classified red meat as "probably carcinogenic to humans" (Group 2A). In mechanistic studies exploring the link between intake of red meat and CRC, heme iron, the pigment of red meat, is proposed to play a central role as a catalyzer of luminal lipid peroxidation and cytotoxicity. In the present work, the novel A/J Min/+ mouse was used to investigate the effects of dietary beef, pork, chicken, or salmon (40% muscle food (dry weight) and 60% powder diet) on Apc-driven intestinal carcinogenesis, from week 3-13 of age. Muscle food diets did not differentially affect carcinogenesis in the colon (flat ACF and tumors). In the small intestine, salmon intake resulted in a lower tumor size and load than did meat from terrestrial animals (beef, pork or chicken), while no differences were observed between the effects of white meat (chicken) and red meat (pork and beef). Additional results indicated that intestinal carcinogenesis was not related to dietary n-6 polyunsaturated fatty acids, intestinal formation of lipid peroxidation products (thiobarbituric acid reactive substances, TBARS), or cytotoxic effects of fecal water on Apc(-/+) cells. Notably, the amount of heme reaching the colon appeared to be relatively low in this study. The greatest tumor load was induced by the reference diet RM1, underlining the importance of the basic diets in experimental CRC. The present study in A/J Min/+ mice does not support the hypothesis of a role of red meat in intestinal carcinogenesis.
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