Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy
2021
Kerckhove, Nicolas | Selvy, Marie | Lambert, Céline | Gonneau, Coralie | Feydel, Gabrielle | Pétorin, Caroline | Vimal-Baguet, Agnès | Melnikov, Sergey | Kullab, Sharif | Hebbar, Mohamed | Bouché, Olivier | Slimano, Florian | Bourgeois, Vincent | Lebrun-Ly, Valérie | Thuillier, Frédéric | Mazard, Thibault | Tavan, David | Benmammar, Kheir Eddine | Monange, Brigitte | Ramdani, Mohamed | Péré-Vergé, Denis | Huet-Penz, Floriane | Bedjaoui, Ahmed | Genty, Florent | Leyronnas, Cécile | Busserolles, Jérôme | Trévis, Sophie | Pinon, Vincent | Pezet, Denis | Balayssac, David | Neuro-Dol (Neuro-Dol) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA) | Direction de la Recherche Clinique et de l’Innovation [CHU Clermont-Ferrand] (DRCI) ; CHU Clermont-Ferrand | Institut Analgesia | Service Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand] ; CHU Estaing [Clermont-Ferrand] ; CHU Clermont-Ferrand-CHU Clermont-Ferrand-Pôle Spécialités médicales et chirurgicales [CHU Clermont-Ferrand] ; CHU Clermont-Ferrand | Centre Hospitalier Saint-Flour (CH Saint-Flour) | Centre hospitalier Moulins-Yzeure [Moulins] (CH Moulins-Yzeure) | Service d'oncologie médicale (CHRU Lille) ; Centre Hospitalier Régional Universitaire [CHU Lille] (CHRU Lille) | Hôpital universitaire Robert Debré [Reims] (CHU Reims) | Biospectroscopie Translationnelle - EA 7506 (BIOSPECT) ; Université de Reims Champagne-Ardenne (URCA) | Centre Hospitalier Boulogne-sur-mer | Service d'Oncologie médicale [CHU Limoges] ; CHU Limoges | Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM) ; CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) | Clinique de l'Infirmerie Protestante de Lyon (CIPL) | Centre Hospitalier Emile Roux [Le Puy-en-Velay] (CH Le Puy-en-Velay) | Centre Hospitalier de Béziers | Centre hospitalier Saint Joseph - Saint Luc [Lyon] | Centre Hospitalier Alpes-Léman - CHAL | Centre Hospitalier Intercommunal Les Hôpitaux du Léman (CHI Les Hôpitaux du Léman) | Centre Hospitalier de Vichy (CH Vichy) | Groupe Hospitalier Mutualiste de Grenoble (GHM) | Service Pharmacie Centrale [CHU Clermont-Ferrand] ; CHU Gabriel Montpied [Clermont-Ferrand] ; CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand] ; CHU Clermont-Ferrand-CHU Louise Michel [Clermont-Ferrand] ; CHU Clermont-Ferrand-Pôle Pharmacie [CHU Clermont-Ferrand] ; CHU Clermont-Ferrand | Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA) | CHU Clermont-Ferrand
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Show more [+] Less [-]English. Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients’ characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management.
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