Cichorium intybus L. Hairy Roots as a Platform for Antimicrobial Activity
2023
Häkkinen, Suvi T. | Cankar, Katarina | Nohynek, Liisa | van Arkel, Jeroen | Laurel, Markus | Oksman-Caldentey, Kirsi Marja | Van Droogenbroeck, Bart
Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant Staphylococcus aureus was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents.
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