Anti-diabetic and Lipid Profile Effect of Astragalus membranaceus (Fisch.) Bunge Fermented by Aspergillus awamori in db/db Mice
2021
Lee, E.J. | Choi, H. | Yoon, W.C. | Kim, Y.S. | Song, B.N. | Lee, M.Y. | Park, B.R. | Lee, S.H. | Choi, J.H. | Park, S.Y.
BACKGROUND: This study investigated the anti-diabetic effects of Astragalus membranaceus (Fisch.) Bunge fermented by Aspergillus awarmori in db/db mice. METHODS AND RESULTS: Astragalus membranaceus roots were fermented with A. awarmori for 4 days and extracted with hot water. The male mice were divided into five groups: db/m (non-diabetic db/+mice), db/db (C57BLKs/J db/db mice), MT (db/db + 1% metformin), AM (db/db + 1% A. membranaceus extract), and FAM (db/db + 1% fermented A. membranaceus extract). After 10 weeks of treatment, we measured the body weight, food intake, and blood glucose, hemoglobin A1C (HbA1c), plasma insulin, adiponectin, and transaminase levels. Oral glucose tolerance test was performed and serum lipid profile was determined. As expected, the AM and FAM groups had significantly reduced body weight, fasting glucose, lipid content, and HbA1c, transaminase, and serum insulin levels, and increased serum adiponectin levels. CONCLUSIONS: Therefore, based on these research results, A. membranaceus extract and fermented A. membranaceus extract can be used to prevent and treat type 2 diabetes by reducing blood glucose levels and lipid content.
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