Moderate adiposity levels counteract protein metabolism modifications associated with aging in rats
2022
Atallah, Nathalie | Gaudichon, Claire, C. | Boulier, Audrey | Baniel, Alain | Azzout-Marniche, Dalila | Khodorova, N. | Chaumontet, Catherine, C. | Piedcoq, Julien | Chapelais, Martin | Calvez, Juliane | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Institut Charles Viollette (ICV) - ULR 7394 (ICV) ; Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Ingredia S.A.
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Show more [+] Less [-]English. Physiological parameters such as adiposity and age are likely to infuence protein digestion and utilization. The aim of this study was to evaluate the combined efects of age and adiposity on casein protein and amino acid true digestibility and its postprandial utilization in ratsFour groups were included (n=7/8): 2 months/normal adiposity, 2 months/high adiposity, 11 months/normal adiposity and 11 months/high adiposity. Rats were given a calibrated meal containing 15N-labeled casein (Ingredia, Arras, France) and were euthanized 6 h later. Digestive contents were collected to assess protein and amino acid digestibilities. 15N enrichments were measured in plasma and urine to determine total body deamination. Fractional protein synthesis rate (FSR) was determined in diferent organs using a fooding dose of 13C valine.Nitrogen and amino acid true digestibility of casein was around 95–96% depending on the group and was increased by 1% in high adiposity rats (P=0.04). Higher adiposity levels counteracted the increase in total body deamination (P=0.03) that was associated with older age. Signifcant efects of age (P=0.006) and adiposity (P=0.002) were observed in the muscle FSR, with age decreasing it and adiposity increasing it.This study revealed that a higher level of adiposity resulted in a slight increase in protein and individual amino acid true digestibility values and seemed to compensate for the metabolic postprandial protein alterations observed at older age.
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