Transcriptome of tambaqui Colossoma macropomum during gonad differentiation: Different molecular signals leading to sex identity
2020
Lobo, Igor Kelvyn Cavalcante | Do Nascimento, Aquila Rodrigues | Yamagishi, Michel Eduardo Beleza | Guiguen, Yann | Silva, Gilvan Ferreira Da | Severac, Dany | Amaral, Aldessandro da Costa | Reis, Vanessa Ribeiro | Almeida, Fernanda Loureiro De | Laboratoire de Physiologie et Génomique des Poissons = Fish Physiology and Genomics Institute (LPGP) ; Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Institut de Génomique Fonctionnelle - Montpellier GenomiX (IGF MGX) ; Institut de Génomique Fonctionnelle (IGF) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-BioCampus (BCM) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) | Universidade Federal do Amazonas (UFAM) | The study wasfinancially supported by Embrapa (SEG03.13.09.010.00.00), the fellowship grants were supported by ADAPTA-II (465540/2014-7) to Igor Kelvyn Cavalcante Lobo and by CAPES to Vanessa Ribeiro Reis | France Génomique National infrastructure funded as part of Investissement d'avenir ”program managed by Agence Nationale pour la Recherche (contract ANR-10-INBS-09) | ANR-10-INBS-0009,France Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010)
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Show more [+] Less [-]English. Tambaqui (Colossoma macropomum) is the major native species in Brazilian aquaculture, and we have shown that females exhibit a higher growth compared to males, opening up the possibility for the production of all-female population. To date, there is no information on the sex determination and differentiation molecular mechanisms of tambaqui. In the present study, transcriptome sequencing of juvenile trunks was performed to understand the molecular network involved in the gonadal sex differentiation. The results showed that before differentiation, components of the Wnt/beta-catenin pathway, fox and fst genes imprint female sex development, whereas antagonistic pathways (gsk3b, wt1 and fgfr2), sox9 and genes for androgen synthesis indicate male differentiation. Hence, in undifferentiated tambaqui, the Wnt/beta-catenin exerts a role on sex differentiation, either upregulated in female-like individuals, or antagonized in male-like individuals.
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