A Zebrafish Embryo Model to Screen Potential Therapeutic Compounds in Sapindaceae Poisoning | Un modèle d'embryon de poisson zèbre pour cribler les composés thérapeutiques potentiels dans l'empoisonnement par les sapindacées
2024
Wouters, Clovis | Klein, Benjamin | Price, Nicholas | Boemer, François | Voz, Marianne | Votion, Dominique | FARAH - Fundamental and Applied Research for Animals and Health - ULiège | FARAH. Médecine vétérinaire comparée - ULiège
English. peer reviewed
Show more [+] Less [-]English. Hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG) are protoxins produced by Sapindaceae plants, particularly Acer pseudoplatanus, and are responsible for causing atypical myopathy (AM) in equids. These protoxins metabolise into toxic compounds, such as methylenecyclopropylacetyl-CoA (MCPA-CoA), which alters energy metabolism and induces severe rhabdomyolysis. Currently, no specific treatment exists for this poisoning, in vitro models fail to reproduce HGA’s toxic effects on equine primary myoblasts, and mammalian models are impractical for large-scale drug screening. This study aimed to develop a zebrafish embryo model for screening therapeutic compounds against AM.
Show more [+] Less [-]15. Life on land
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