Optimization of Liquid-Liquid Phthalates Extraction from Artficial Saliva
2024
Bogdanović, Danica | Anđelković, Tatjana | Kostić Kokić, Ivana | Milovanović, Marina
Children often come into contact with toys made of polyvinyl chloride (PVC) in their earliest years, during the period when they put toys into mouth. For this reason, the aim of this work was optimization the liquid-liquid extraction of phthalates from artificial saliva, in order to determine the most favourable conditions under which the maximum migration of phthalates into the appropriate extraction agent occurs. The analyzed phthalates were dimethyl phthalate (DMP), di-n-butyl phthalate (DBP), benzylbutyl phthalate (BBP), di-2-ethylhexyl phthalate (DEHP) and di-n-octyl phthalate (DOP). The gas-chromatography coupled with mass-spectrometry (GC-MS) technique for the phthalates quantitative determination were used. The applied parameters of extraction were different extraction agent, agitation time, agitation type, application of reextraction, evaporation of the extract to dryness and evaporation to about 1 mL. The parameters that gave the best recovery values for all investigated phthalates are the application of n-hexane, manual shaking, shaking in an ultrasonic bath, evaporation of the extract to a volume of about 1 mL.
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Publisher University of Belgrade, Technical faculty in Bor (Serbia)
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