Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats
2020
Qian Zhou | Lei Ma | Wenyang Zhao | Wen Zhao | Xue Han | Jiahui Niu | Rongbin Li | Changhui Zhao
Flaxseed oil is a type of herbal oil obtained from the ripened seeds of the flax plant (Linum usitatissimum L.) that is widely utilized for baked foods. The aim of present study was to investigate the effect of flaxseed oil on ulcerative colitis. The rats were gavaged daily with flaxseed oil at doses of 400, 800 and 1600 mg/kg b.w. for six weeks, while ulcerative colitis was induced by daily administrating with 3% (w/v) dextran sulfate sodium (DSS) on the sixth week. Results showed that the rats fed with flaxseed oil had less disease activity index, colon weight, colon weight/length ratio and colon cell damage. Flaxseed oil consumption relieved the oxidative condition, reduced colon inflammation and partly restored the microbiota change by DSS. Flaxseed oil (1600 mg/kg b.w.) has a great potential in prevention of ulcerative colitis possibly by regulating the oxidative condition, inflammatory factors and cecal microbiota.
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