Omega-3 fatty acids mediated Cellular signaling and its regulation in Human Health
2023
Avijit Kar | Pratik Ghosh | Prasanta Patra | Deep Sankar Chini | Ashim Kumar Nath | Jayanta Kumar Saha | Bidhan Chandra Patra
Summary: Long-chain Polyunsaturated Fatty Acids (PUFAs) especially n-3 series such as Omega-3, Docosahexaenoic Acid (DHA), and Eicosapentaenoic Acid perform as necessary dietary supplements to consider the well-being of human health. Notably, these FAs evoked specific protein targeting biogenesis pathways in the cytosol that prevents various human disorders likewise; as coronary heart disease, inflammatory disease, liver problems, diabetes, brain development, eye problems, cancer therapy as well as therapy in COVID-19. In the protein regulation, PUFAs alter the composition of membrane lipids, modulation of cyclooxygenase, activation of SIRT1/AMPK, control intracellular metabolism, control the signal transduction along with gene expression, and regulates transcription factors like SREBF1c as well as nuclear receptors HNF-4, GPCR, PPAR, LXR, TLR-4, etc. Thus, the present article focuses on the potential cytotoxic therapeutic role and pleiotropic effects of n-3 PUFAs against chronic inflammations, platelet aggregation, coronary diseases, retinal disorder, and cancer cell proliferation in human body.
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