PROFILES OF OMEGA 6 FATTY ACIDS OF BLACK CUMIN OIL IN THE CORK-BASED ALBUMIN OINTMENT FOR WOUND CLOSURE
2020
Suprayitno E.
The components for wound closure consist of albumin, collagen, omega 3, and omega 6. Black cumin oil (habattussauda or Nigella sativa) has been known to contain much of oleic and linoleic fatty acids, the kind of fatty acids available abundantly in nature. Albumin from cork fish (Channa striata), collagen from the skin of grouper fish, omega 3 from flaxseed oil, and omega 6 from black cumin oil are used as active ingredients in making ointments to speed up the process of wound closure. An ointment is a thick substance, usually containing medicine, that is put on the skin where it is sore or where there is an injury, to cure it. The results from phase 1 of the study showed that different concentrations of black cumin oil affected the quality of the albumin ointment in terms of pH, viscosity, omega 3 content, protein content, fat content, water content, fatty acid profile, and zinc content. The best albumin ointment was produced at the 5 mL concentration of the black cumin oil with the following results: 6.9 pH, viscosity 16844 cP, 17.33% omega 3, 2.73% protein content, 87.92% fat content, and 5.5% water content. The best ointment produced was then used in an experiment on mice. Observations on day 3, 5, and 7 showed the fastest wound closure process using the albumin ointment with 75% wound closure happened on day 7.
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