Antihypertensive activities of the plasteins derived from casein hydrolysates in spontaneously hypertensive rats
2017
Jin-Long Xu | Jia-Nan Pang | Fang-Fang Chen | Tie-Jing Li | Xin-Huai Zhao
Two casein plasteins were prepared from the Neutrase-catalyzed plastein reaction of casein hydrolysates in the presence of proline and phenylalanine, respectively, and assessed for their antihypertensive activities at 300 mg/kg body using rat model. After being oral administered, the two plasteins at initial time of 2–6 h resulted in the rats decreased systolic and diastolic blood pressures of 10–23 and 8–19 mmHg, respectively; however, the measured antihypertensive activities showed decreasing trends as oral administrating time prolonged. The two plasteins also decreased serum levels of angiotensin II, angiotensin I converting enzyme, and aldosterone, but had unclear effect on serum angiotensinogen level. The two plasteins showed same antihypertensive activities without statistical difference (p > 0.05), and were more efficient than casein hydrolysates but less effective than captopril (p < 0.05) to exert antihypertensive effect. It is concluded that the plastein reaction can confer casein hydrolysates with enhanced in vivo antihypertensive activities.
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