COMPARATIVE PHARMACOKINETIC STUDIES ON OXYTETRACYCLINE IN CAMELS, SHEEP AND GOATS
2003
Mohammed H. Al-Nazawi
Kinetics of long-acting oxytetracycline (OTC) injected intravenously (IV) at a dose of 5 mg/kg was determined in each of eight camels, sheep and goats. The disposition of OTC was described by two-compartment open model. Two elimination half-lives were recorded for the camel (81 min and 46.1 h), whereas in sheep and goats these were 3.2 and 3.4 h, respectively. The peak plasma concentration was 10.2, 850 and 780 g/ml at 5 minutes in camel, sheep and goats, respectively. The values of volume of distribution were 1.4, 13.4 and 12.1 litre/kg for the camels, sheep and goats, respectively. In sheep and goats, values of t1/2, Vd and clearance were found similar but different from camel, indicating exclusive distribution and substantial storage which were consistent with oxytetracycline lipophilicity and the large fat content of camel body.
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