The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies
2020
Donghyun Kang | Jeeyeon Lee | Cuiyan Wu | Xiong Guo | Byeong Jae Lee | Jang-Soo Chun | Jin-Hong Kim
Joint health: the rare micronutrient selenium may be crucial Selenium, a micronutrient found in brazil nuts, shiitake mushrooms, and most meats, may aid in treating joint diseases, including the most common form of arthritis, osteoarthritis (OA). In addition to thyroid hormone metabolism and immunity, selenium is important in antioxidant defense. Oxidative damage can destroy cartilage and harm joints, and selenium deficiency is implicated in several joint diseases. Jin-Hong Kim at Seoul National University in South Korea and co-workers reviewed selenium metabolism, focusing on OA and and Kashin–Beck disease, a skeletal development disorder prevalent in selenium-deficient areas of northeast Asia. They report that selenium-containing proteins protect cells against oxidative damage and that selenium is crucial to cartilage production. Further investigation of selenium metabolism may point the way to new treatments for OA and other joint diseases.
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