Relative contributions of α-, β-, and ω-oxidative pathways to in vitro fatty acid oxidation in rat liver
1968
Gabor J. Antony | Bernard R. Landaus
A method is presented for estimating the relative contribution of α-, β-, and ω-oxidation to the metabolism of fatty acids. The distribution of 14C among the carbon atoms of liver glycogen-glucose is determined after liver slices have been incubated with fatty acids labeled at single points in the chain. When these results are compared with similar data obtained after an incubation with acetate-1-14C and acetate-2-14C, conclusions can be drawn about the contributions of α-, β-, and ω-oxidation in palmitate, oleate, and stearate, and of oxidative cleavage of the double bond in oleate. β-Oxidation is overwhelmingly predominant under the conditions used.
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