Catalyst-free electrochemical dearomatization of pyridine derivatives
2024
Kui Wang | Yingjun Tian | Baoying Li | Ling Wang | Wei Gao | Xiaofei Jia | Ruiming Wang | Yanping Zhu | Jianbin Chen
We demonstrated herein an electrochemical dearomatizative alkylation of Katritzky salts, wherein Katritzky salts were harnessed as both radical acceptors and donors. A wide range of privileged dihydropyridine scaffolds was constructed with good to excellent yields. Cyclic voltammetry (CV) and electron paramagnetic resonance (EPR) results confirmed the key intermediates-dihydropyridine radicals and gram-scale reaction highlighted the practical and sustainable feature of the newly developed protocol.
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