Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice
2021
Ashley M. Fields | Kevin Welle | Elaine S. Ho | Clementina Mesaros | Martha Susiarjo
Fields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β-cell proliferation, showing that vitamin B6 deficiency regulates maternal glucose tolerance in a serotonin-dependent manner.
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