The peculiarities of operation of glutathione component of antioxidant protection and lipid metabolism in pregnant rat females under the action of chromium citrate
2013
R. Ya. Iskra
The effect of chromium citrate in dose of 10 µg Cr (ІІІ)/ kg body weight on functioning of the glutathione antioxidant system level and lipid metabolism in pregnant female rats has been studied. Growth of the reduced glutathione content in blood, liver, spleen, and myocardium of female rats of the experimental group against the backdrop of increasing glutathione reductase activity in these tissues has been established. At the same time, growth of glutathione peroxidase activity in the myocardium of females rats, and a decrease in lungs and foetus was found. An increase in glucose-6-phosphate dehydrogenase activity in the myocardium, and the decline in kidney and spleen have been shown. Lowering in triacylglycerols in blood of female rats of the experimental group compared to the control was detected. Thus, administration of chromium citrate in quantity of 10 mg Cr (ІІІ) /kg body weight, enhances glutathione link of antioxidant system and normalizes lipid metabolism in pregnant female rats.
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