Box-Jenkins Transfer Function Modelling for Reliable Determination of VO<sub>2</sub> Kinetics in Patients with COPD
2019
Joren Buekers | Jan Theunis | Alberto Peña Fernández | Emiel F. M. Wouters | Martijn A. Spruit | Patrick De Boever | Jean-Marie Aerts
Oxygen uptake (VO<sub>2</sub>) kinetics provide information about the ability to respond to the increased physical load during a constant work rate test (CWRT). Box-Jenkins transfer function (BJ-TF) models can extract kinetic features from the phase II VO<sub>2</sub> response during a CWRT, without being affected by unwanted noise contributions (e.g., phase I contribution or measurement noise). CWRT data of 18 COPD patients were used to compare model fits and kinetic feature values between BJ-TF models and three typically applied exponential modelling methods. Autocorrelation tests and normalised root-mean-squared error values (BJ-TF: 2.8 ± 1.3%; exponential methods A, B and C: 10.5 ± 5.8%, 11.3 ± 5.2% and 12.1 ± 7.0%; <i>p</i> < 0.05) showed that BJ-TF models, in contrast to exponential models, could account for the most important noise contributions. This led to more reliable kinetic feature values compared to methods A and B (e.g., mean response time (MRT), BJ-TF: 74 ± 20 s; methods A-B: 100 ± 56 s−88 ± 52 s; <i>p</i> < 0.05). Only exponential modelling method C provided kinetic feature values comparable to BJ-TF features values (e.g., MRT: 75 ± 20 s). Based on theoretical considerations, we recommend using BJ-TF models, rather than exponential models, for reliable determinations of VO<sub>2</sub> kinetics.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Directory of Open Access Journals