Molecular modelling of FtsZ proteins based on their homology in Escherichia coli and Mycobacterium tuberculosis as the key stage of rational design of new antituberculous compounds
2011
Oleh Demchuk | Pavel Karpov | Peter Raspor | Yaroslav Blume
The analysis of the quality of X-ray structures from Mycobacterium tuberculosis FtsZ proteins, which are deposited in the ProteinDataBank, gave a possibility to select a 2Q1Y (Chain A) structure as a template for future in silico research. Also several spatial models of FtsZ protein from Escherichia coli were reconstructed with on-line servers »Swiss-Model Workspace« and I-Tasser, than the most appropriate structure was selected. Basing on complex bioinformatic study, the model, which was rebuilt by SwissModel server from 2Q1Y (chain A) template, was supposed as the most significant.
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