Antioxidant Efficacy of a <i>Spirulina</i> Liquid Extract on Oxidative Stress Status and Metabolic Disturbances in Subjects with Metabolic Syndrome
2022
N’Deye Lallah Nina Koite | N’gouro Issa Sanogo | Olivier Lépine | Jean-Marie Bard | Khadija Ouguerram
Lipid peroxidation is associated with the development of some pathologies, such as cardiovascular diseases. Reduction in oxidative stress by antioxidants, such as <i>Arthrospira</i> (formely <i>Spirulina</i>), helps improving this redox imbalance. The aim of the study was to evaluate the effect of the <i>Arthrospira</i> liquid extract “Spirulysat<sup>®</sup>” on oxidative markers—in particular, oxidized LDL (oxLDL)/total LDL cholesterol—and isoprostanes and to investigate its impact on lipid and glucose metabolism in the metabolic syndrome subject. A controlled, randomised, double-blind design was conducted in 40 subjects aged 18 to 65 years with metabolic syndrome after a daily intake of Spirulysat<sup>®</sup> or placebo for twelve weeks. Blood and urinary samples were collected at three visits (V1, V2, V3) in the two groups for parameters determination. Although the Spirulysat<sup>®</sup> group showed a decrease at all visits of the oxLDL/total cholesterol ratio, there was no significant difference compared to the placebo (<i>p</i> = 0.36). The urinary isoprostanes concentration in the Spirulysat<sup>®</sup> group was reduced (<i>p</i> = 0.014) at V3. Plasma triglycerides decreased at V3 (<i>p</i> = 0.003) and HDL-cholesterol increased (<i>p</i> = 0.031) at all visits with Spirulysat<sup>®</sup>. In conclusion, Spirulysat<sup>®</sup> did not change the oxidized LDL (oxLDL)/LDL ratio but decreased the urinary isoprostanes, plasma triglycerides and increased HDL cholesterol, suggesting a beneficial effect on metabolic syndrome.
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