Mechanical Characteristics and Bioactivity of Nanocomposite Hydroxyapatite/Collagen Coated Titanium for Bone Tissue Engineering
2022
Diana Julaidy Patty | Ari Dwi Nugraheni | Ika Dewi Ana | Yusril Yusuf
In the present study, we have analyzed the mechanical characteristics and bioactivity of titanium coating with hydroxyapatite/bovine collagen. Hydroxyapatite (HAp) was synthesized from a Pinctada maxima shell and has a stoichiometry (Ca/P) of 1.72 and a crystallinity of 92%, suitable for coating materials according to ISO and Food and Drug Administration (FDA) standards. Titanium (Ti) substrate coatings were fabricated at HAp concentrations of 1% (Ti/HAp-1) and 3% (Ti/HAp-3) and a bovine collagen concentration of 1% (Ti/HAp/Coll) by the electrophoresis deposition (EPD) method. The compressive strength of Ti/HAp-1 and Ti/HAp-3 was 87.28 and 86.19 MPa, respectively, and it increased significantly regarding the control/uncoated Ti (46.71 MPa). Furthermore, the Ti/HAp-coll (69.33 MPa) has lower compressive strength due to collagen substitution (1%). The bioactivity of Ti substrates after the immersion into simulated body fluids (SBF) for 3–10 days showed a high apatite growth (Ca<sup>2+</sup> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mrow><mi>PO</mi></mrow><mn>4</mn><mrow><mn>3</mn><mo>−</mo></mrow></msubsup></mrow></semantics></math></inline-formula>), according to XRD, FTIR, and SEM-EDS results, significantly on the Ti/HAp-coll.
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