Algal-Derived Halogenated Sesquiterpenes from <i>Laurencia dendroidea</i> as Lead Compounds in Schistosomiasis Environmental Control
2022
Guilherme Senna dos Santos | Patrícia Aoki Miyasato | Erika Mattos Stein | Pio Colepicolo | Anthony D. Wright | Carlos Alberto de Bragança Pereira | Miriam Falkenberg | Eliana Nakano
Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, <i>Laurencia dendroidea</i>, whose extracts demonstrated significant activity toward both <i>Schistosoma mansoni</i> parasites and their intermediate host snails <i>Biomphalaria glabrata</i>. In the present study, three seaweed-derived halogenated sesquiterpenes, (−)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against <i>S. mansoni</i> cercariae and <i>B. glabrata</i> embryos. Biomonitored fractioning of <i>L. dendroidea</i> extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos.
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