Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway
2020
Luo Yi-Ran | Zhou Shu-Ting | Yang Liang | Liu Yuan-Ping | Jiang Sheng-Yao | Dawuli Yeliboli | Hou Yi-Xuan | Zhou Tian-Xing | Yang Zhi-Biao
Porcine epidemic diarrhoea virus (PEDV) infection causes watery diarrhoea, vomiting, anorexia, and weight loss, especially among neonatal piglets, inflicting on them morbidity and mortality potentially reaching 90%–100%. Despite it being known that certain mammalian cell phases are arrested by PEDV, the mechanisms have not been elucidated, and PEDV pathogenesis is poorly understood. This study determined the effect of an epidemic PEDV strain on cell cycle progression.
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