Factors affecting tolerance and immunoreactivity of rainbow trout (Oncorhynchus mykiss) to polyinosinic-polycytidylic acid
2019
Nishikawa, S. (Hokkaido University, Hakodate, Hokkaido (Japan). Faculty of Fisheries Sciences) | Nakano, T. | Kasai, H.
Polyinosinic-polycytidylic acid (PIC), a synthetic double-stranded RNA, is a strong innate immune response inducer. Although it is an innate immune inducer, when administered to some fish species at low temperatures, PIC may be toxic and mortality may occur. Moreover, in mice, immunoreactivity is affected by nucleotide length of PIC. The aim of this study was to demonstrate the effects of body size, water temperature and length of PIC on tolerance and immunoreactivity of rainbow trout to PIC. Tolerance of fish to PIC was better for large fish (145 g) than for small fish (12 g). Furthermore, PIC-induced Mx gene expression when water temperature was high peaked at day 1 and then decreased sharply. When water temperature was low, Mx gene expression lasted longer and high mortality indicated toxicity of PIC. Observations on the effects of length of PIC revealed that Mx gene expression was not significantly related to the length of PIC.
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