LC/Tribrid Orbitrap analysis of phosphodiesterase-5 inhibitors and their analogs as adulterants in dietary supplements
2019
Sakamoto, M. (Tokyo Metropolitan Institute of Public Health, Shinjuku-ku, Tokyo (Japan)) | Minowa, K. | Kishimoto, K. | Nakajima, J. | Suzuki, J. | Moriyasu, T. | Fukaya, H. | Saito, K.
LC/Tribrid Orbitrap was developed to determine phosphodiesterase-5 (PDE-5) inhibitors and their analogs as adulterants in dietary supplements. High-resolution MS/MS and MSsup(3) spectra of PDE-5 inhibitors and their analogs were obtained by LC/Tribrid Orbitrap using both higher-energy collisional dissociation and collision-induced dissociation. We investigated dietary supplements that claim to enhance men's sexual performance, and detected PDE-5 inhibitors and their analogs. We also estimated the structures of the PDE-5 inhibitor analogs and the impurities of PDE-5 inhibitors and their analogs in the dietary supplements.
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