Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats
2012
González Redondo, Pedro | Manunza, A. | Zidi, A. | Fernández Cabanás, Víctor Manuel | Carrizosa, J. | Belaifa, E. | Urrutia, B. | Polvillo Polo, Oliva | Amills, M. | Serradilla Manrique, Juan Manuel | Universidad de Sevilla. Departamento de Ciencias Agroforestales
Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353CT polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in MurcianoGranadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.
Show more [+] Less [-]Le facteur de transcription de´nomme´ Sterol regulatory element binding transcription factor 1 (SREBF1) re´gule l’expression des ge`nes implique´s dans la biosynthe`se des acides gras et du choleste´rol. Dans cette e´tude, nous avons se´quence´ la quasi-totalite´ de la re´gion codante et une partie du la re´gion 3?UTR du ge`ne SREBF1 de la che`vre. Ce travail, nous a permis d’identifier un polymorphisme non-synonyme c.353CT causant la substitution d’une Proline en Leucine a` la position 118. L’e´tude d’association avec la composition du lait enregistre´e en che`vres Murciano-Granadina, a re´ve´le´ seulement une tendance statistique reliant SREBF1 ge´notype et l’acide gras ome´ga-3 du lait. L’absence d’associations significatives sugge`re que la substitution P118L n’implique pas un changement fonctionnel.
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