Therapeutic Approach to Alzheimer’s Disease: Current Treatments and New Perspectives
2022
Pardo Moreno, Teresa | González Acedo, Anabel | Rivas Domínguez, Antonio | García Morales, Victoria | García Cózar, Francisco José | Ramos Rodríguez, Juan José | Melguizo Rodríguez, Lucía | Universidad de Sevilla. Departamento de Biología Celular | Ministerio de Ciencia e Innovación (MICIN). España | Junta de Andalucía
Alzheimer’s disease (AD) is the most common cause of dementia. The pathophysiology of this disease is characterized by the accumulation of amyloid-β, leading to the formation of senile plaques, and by the intracellular presence of neurofibrillary tangles based on hyperphosphorylated tau protein. In the therapeutic approach to AD, we can identify three important fronts: the approved drugs currently available for the treatment of the disease, which include aducanumab, donepezil, galantamine, rivastigmine, memantine, and a combination of memantine and donepezil; therapies under investigation that work mainly on Aβ pathology and tau pathology, and which include γ-secretase inhibitors, β-secretase inhibitors, α-secretase modulators, aggregation inhibitors, metal interfering drugs, drugs that enhance Aβ clearance, inhibitors of tau protein hyperphosphorylation, tau protein aggregation inhibitors, and drugs that promote the clearance of tau, and finally, other alternative therapies designed to improve lifestyle, thus contributing to the prevention of the disease. Therefore, the aim of this review was to analyze and describe current treatments and possible future alternatives in the therapeutic approach to AD.
Show more [+] Less [-]Ministerio de Ciencia e Innovación PID2020-117544RB-100
Show more [+] Less [-]Junta de Andalucía P20-01293, PECART-0096- 2020
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