Activity of Host Antimicrobials against Multidrug-Resistant Acinetobacter baumannii Acquiring Colistin Resistance through Loss of Lipopolysaccharide
2014
García Quintanilla, Meritxell de Jesús | Pulido, Marina R. | Moreno-Martínez, Patricia | Martín-Peña, Reyes | López Rojas, Rafael | Pachón Díaz, Jerónimo | McConnell, Michael J. | Universidad de Sevilla. Departamento de Microbiología | Universidad de Sevilla. Departamento de Medicina | Universidad de Sevilla. CTS210: Resistencia a Antimicrobianos | Universidad de Sevilla. CTS203: Estudio de las Enfermedades Infecciosas
Acinetobacter baumannii can acquire resistance to the cationic peptide antibiotic colistin through complete loss of lipopolysaccharide (LPS) expression. The activities of the host cationic antimicrobials LL-37 and human lysozyme against multidrug-resistant clinical isolates of A. baumannii that acquired colistin resistance through lipopolysaccharide loss were characterized. We demonstrate that LL-37 has activity against strains lacking lipopolysaccharide that is similar to that of their colistin-sensitive parent strains, whereas human lysozyme has increased activity against colistin-resistant strains lacking LPS.
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Show more [+] Less [-]European\'s Development Regional Fund "A way to achieve Europe" ERDF
Show more [+] Less [-]Ministerio de Economia y Competitividad of Spain CP11/00314
Show more [+] Less [-]Ministerio de Economia y Competitividad, Instituto de Salud Carlos III
Show more [+] Less [-]Spanish Network for the Research in Infectious Diseases REIPI RD06/0008/0000
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