Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin-rich extracts
2017
Corona, Giulia | Coman, Maria Magdalena | Guo, Yuxuan | Hotchkiss, Sarah | Gill, Chris | Yaqoob, Parveen | Spencer, Jeremy P. E. | Rowland, Ian
Although phlorotannins, TP levels and antioxidant power of the extracts were strongly reduced after in vitro digestion and fermentation, their anti-genotoxic activity and cell growth inhibitory effect in colon HT-29 cells was maintained and enhanced. HMW was the most effective fraction, indicating that the high molecular weight phlorotannins potentially exert a stronger beneficial effect in the colon.
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