The effect of leptin gene polymorphisms on fertility traits in Japanese Black cattle
2016
Kawaguchi, F. (Kobe University, Kobe (Japan). Graduate School of Agricultural Science) | Fukazawa, K. | Kohama, N. | Akiyama, T. | Fukushima, M. | Kobayashi, E. | Oyama, K. | Mannen, H. | Sasazaki, S.
In this study, we investigated the effect of leptin gene polymorphisms on fertility traits in Japanese Black cattle of Hyogo Prefecture (n = 409). Three amino acid substitutions (Y7F, R25C, and A80V) were identified by sequence comparison of full-length coding region among 16 animals. We genotyped these substitutions for 409 animals and then analyzed the effects on three fertility traits (calving interval, age at first calving, and the number of calves produced at 4 years of age). As the result, Y7F and R25C were associated with the calving interval (P < 0.05). In addition, Y7F and R25C were in strong linkage disequilibrium (r**2 = 0.88). However, Y7F is not so important in mature leptin because this position is cleaved off before leptin is excreted from the adipose tissue. These results suggested that the effect of Y7F on the calving interval may be due to the linkage disequilibrium with R25C and R25C would be used as effective DNA marker for the improvement of calving interval.
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