New PKS/NRPS Tenuazamines A–H from the Endophytic Fungus <i>Alternaria alternata</i> FL7 Isolated from <i>Huperzia serrata</i>
2024
Hao Zhang | Zhibin Zhang | Yiwen Xiao | Wen Wang | Boliang Gao | Yuhao Xie | Jiahao Xie | Xinhua Gao | Du Zhu
In this paper, we present a novel class of hybrid polyketides, tenuazamines A–H (<b>1</b>–<b>8</b>), which exhibit a unique tautomeric equilibrium from <i>Alternaria alternata</i> FL7. The elucidation of the structures was achieved through a diverse combination of NMR, HR-ESIMS, and ECD methods, with a focus on extensive spectroscopic data analysis. Notably, compounds <b>1</b>, <b>4</b>, <b>8</b>–<b>9</b> exhibited potent toxic effects on the growth of <i>Arabidopsis thaliana</i>. This research expands the structural diversity of tenuazonic acid compounds derived from endophytic fungi and provides potential hit compounds for the development of herbicides.
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