Synergy between Lactobacillus murinus and anti-PcrV antibody delivered in the airways to boost protection against Pseudomonas aeruginosa
2024
Secher, Thomas | Cortes, Mélanie | Boisseau, Chloé | Barba Goudiaby, Marie-Thérèse | Pitiot, Aubin | Parent, Christelle | Thomas, Muriel | Heuzé-Vourc’h, Nathalie | Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR) ; Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM) | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | FHU Paris Center for Microbiome Medicine (FHU PaCeMM) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) | Université de Tours (UT) | Region Centre-Val-de-Loire (Novantinh Program) C-VALO (Infinhitim Program)
International audience
Show more [+] Less [-]English. Therapeutic antibodies (Ab) have revolutionized the management of multiple illnesses including respiratory tract infections (RTIs). However, anti-infectious Ab displayed several limitations including antigen restrictiveness, narrowed therapeutic windows and limited dose in the vicinity of the target when delivered by parenteral routes. Strategies enhancing further Ab-dependent containment of infection is currently needed. Here we showed that a combination of inhaled anti-infectious Ab and probiotics is an efficient formulation to protect against lung infection. Using a mouse model of Pseudomonas aeruginosa -induced pneumonia, we demonstrated a synergistic effect reducing both bacterial burden and pro-inflammatory response affording protection against primary and secondary infections. This is the first study showing that the local combination of anti-infective Ab and probiotics, subverts suboptimal potency of Ab monotherapy and provides local protection against respiratory pathogen.
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