Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review
2024
Veal, Christopher | Tomlinson, Anneka | Cipriani, Andrea | Bulteau, Samuel | Henry, Chantal | Müh, Chlöé | Touboul, Suzanne | de Waal, Nikki | Levy-Soussan, Hana | Furukawa, Toshi | Fried, Eiko | Tran, Viet-Thi | Chevance, Astrid | Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | University of Oxford | Oxford Health NHS Foundation Trust | Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance (MIP) ; Le Mans Université (UM)-Nantes Université - UFR des Sciences et Techniques des Activités Physiques et Sportives (Nantes Univ - UFR STAPS) ; Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) | MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE) ; Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Univ - UFR Pharmacie) ; Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé ; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) | Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) | Université Paris Cité (UPCité) | Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] (GHU Paris Psychiatrie et Neurosciences) | Perception et Mémoire / Perception and Memory ; Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) | Collège Doctoral ; Sorbonne Université (SU) | Auteur indépendant | La Maison Perchée [Paris] | Kyoto University | Universiteit Leiden = Leiden University | GHU AP-HP Nord - Université Paris Cité
International audience
Show more [+] Less [-]English. Research waste occurs when randomised controlled trial (RCT) outcomes are heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or functions). In this systematic review, we reviewed the outcome measures used in 450 RCTs of adult unipolar and bipolar depression registered between 2018 and 2022 and identified 388 different measures. 40% of the RCTs used the same measure (Hamilton Depression Rating Scale [HAMD]). Patients and clinicians matched each item within the 25 most frequently used measures with 80 previously identified domains of depression that matter to patients. Seven (9%) domains were not covered by the 25 most frequently used outcome measures (eg, mental pain and irritability). The HAMD covered a maximum of 47 (59%) of the 80 domains that matter to patients. An interim solution to facilitate evidence synthesis before a core outcome set is developed would be to use the most common measures and choose complementary scales to optimise domain coverage. TRANSLATIONS: For the French and Dutch translations of the abstract see Supplementary Materials section.
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