Erythrocyte magnesium influx and efflux in solid tumor bearing mice
2005
Feillet Coudray, Christine | Nasulewicz, Anna | Jaffrelo, Lydia, L. | Thien, Séverine | Coudray, Charles, C. | Rambeau, Mathieu | Gueux, Elyette | Rayssiguier, Yves | Opolski, Adam | Wolf, Frederica | Mazur, André | Unité de recherche Maladies Métaboliques et Micronutriments (U3M) ; Institut National de la Recherche Agronomique (INRA) | Centre de Recherche en Nutrition Humaine | Institute of Immunology and Experimental Therapy ; Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences (PAN) | Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt)
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Show more [+] Less [-]English. Mg metabolism is modified in tumors and tumor-bearing organisms. In particular cancer patients often display elevated erythrocyte Mg levels. For a better understanding of the increased erythrocyte Mg content, we attempted to determine Mg fluxes in erythrocytes from tumor-bearing mice by Mg stable isotopes, using a method developed in our laboratory. To characterize the animal Mg status, blood and tissue Mg levels and hematological parameters were assayed. Results showed that in tumor-bearing mice total erythrocyte Mg was about 46% higher than in controls, whereas plasma and tissues Mg levels were not modified; red blood cells and hemoglobin as well as hematocrits were significantly decreased, while mean corpuscular volume and mean corpuscular hemoglobin were slightly but significantly increased in tumor-bearing mice compared to controls (by 3% and 4%, respectively), a picture corresponding to a normochromic, slightly macrocytic anemia. Erythrocyte Mg efflux was about 20% higher (404 + 59 versus 330 + 45 micromol/L, respectively, p < 0.05) in tumor-bearing mice compared to controls, whereas influx was not significantly modified (130 + 11 versus 122 + 19 micromol/L, respectively). Our data therefore exclude that the increased Mg content observed in erythrocytes of tumor-bearing mice is due to decrease of Mg efflux, or to an increase of Mg influx. On the other hand, the increased Mg content observed in erythrocytes of tumor-bearing mice could simply result from an increase of young Mg-enriched erythrocytes produced by the enhanced erythropoiesis which follows tumor-induced anemia.
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