<em>Candida albicans</em> bloodstream isolates in a German university hospital are genetically heterogenous and susceptible to commonly used antifungals
2015
Huyke, Johanna | Martin, Ronny | Walther, Grit | Weber, Michael | Kaerger, Kerstin | Bougnoux, Marie-Elisabeth | Elias, Johannes | Kurzai, Oliver | Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute) | Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany] | Leibniz Institute for Natural Product Research and Infection Biology ; Hans Knoell Institute | Biologie et Pathogénicité fongiques (BPF) ; Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP) | Hôpital Necker - Enfants Malades [AP-HP] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Faculté de Médecine ; Université de Ngozi [Burundi] | Julius-Maximilians-Universität Würzburg = University of Würzburg [Würsburg, Germany] (JMU) | Wellcome Trust; Robert-Koch-Institute from funds provided by the German Ministry of Health (grant-No.1369-240)
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Show more [+] Less [-]English. From an eight-year-span, 99 Candida bloodstream isolates were collected at the University Hospital Wuerzburg, Germany. In this study, all strains were analyzed using molecular and phenotypic typing methods. Confirmatory species identification revealed three isolates that were initially diagnosed as C. albicans to be actually C dubliniensis. Two isolates contained a mixed culture of C albicans and C glabrata, in one of the specimens both species could be separated while it was not possible to recover C albicans in the other sample. The remaining 95 C albicans isolates were profiled by multilocus sequence typing (MLST). Phylogenetic analyses showed a highly heterogenous collection of strains, associated with many different clades and constituting a set of new diploid sequence types (DST). For all strains with identical DST, patient data were reviewed for potential nosocomial transmission. In addition, all isolates were tested for their susceptibility to amphotericin B, caspofungin, fluconazole, itraconazole, posaconazole and voriconazole. No clinically relevant resistance could be detected. Furthermore, these data underline that correlation between minimal inhibitory concentrations for caspofungin and anidulafungin is low.
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