In vitro models for investigation of the host-parasite interface - possible applications in acute Chagas disease
2020
Breyner, Natália Martins | Hecht, Mariana | Nitz, Nadjar | Rose, Ester | Carvalho, Juliana Lott | ToxAlim (ToxAlim) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Universidade de Brasilia = University of Brasilia [Brasília] (UnB) | Universidade Católica de Brasília=Catholic University of Brasília (UCB) | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq: 421897/2016-3), and Fundacao de Apoio a Pesquisa do Distrito Federal) (FAPDF): 193.001.471/2017.
International audience
Show more [+] Less [-]English. Chagas disease (CD), caused by Trypanosoma cruzi, is the main parasitic disease in the Western Hemisphere, with an increasing number of cases, especially in non-endemic regions. The disease is characterized by cardiomegaly and mega viscera, nevertheless, the clinical outcome is hard to predict, underscoring the need for further research into the pathophysiology of CD. Even though most basic and translational research involving CD is performed using in vivo models, in vitro models arise as an ethical, rapidly evolving, and physiologically relevant alternative for CD research. In the present review, we discuss the past and recent in vitro models available to study the host-parasite interface in cardiac and intestinal CD, critically analyzing the possibilities and limitations of state-of-the-art alternatives for the CD host-parasite investigation.
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Bibliographic information
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