Using murine colitis models to analyze probiotics–host interactions
2017
Martin Rosique, Rebeca | Chain, Florian | Miquel, Sylvie | Motta, Jean-Paul | Vergnolle, Nathalie | Sokol, Harry | Langella, Philippe | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Laboratoire Microorganismes : Génome et Environnement (LMGE) ; Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS) | Institut de Recherche en Santé Digestive (IRSD) ; Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Department of Biological Science, Inflammation Research Network ; University of Calgary | Equipe de Recherche Labelisée (ERL) 1157, Avenir Team Gut Microbiota and Immunity ; Institut National de la Santé et de la Recherche Médicale (INSERM) | Université Pierre et Marie Curie - Paris 6 (UPMC)
Probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.
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